Apoptosis is generally defined as cell death, often programmed into the genes; with nitrous oxide-induced cell death, however, brain cells associated with learning and memory are killed due to lack of oxygen.

There are two forms of brain damage associated with long-term exposure to nitrous oxide: apoptosis and myeloneuropathy. José Castillo, Ramón Rama, and ; Antoni Dávalos; From the Department of Neurology, Complejo Hospitalario Universitario, Santiago de Compostela (J.C.); Department of Physiology, Universidad de Barcelona, Barcelona (R.R. Severe B12 deficiency can lead to serious nerve damage, causing tingling and numbness in the fingers and toes. This is a common misconception. Heavy regular use of nitrous oxide can lead to a deficiency of vitamin B12 and to a form of anaemia. However, it is important to understand what abuse of nitrous oxide can do to you and your brain.

“The biggest danger from whippits is that when you are not using nitrous with oxygen, you can be in a hypoxic state.” If severe hypoxia continues for more than a few minutes, it can lead to brain damage or even death. Nitric Oxide–Related Brain Damage in Acute Ischemic Stroke. Apoptosis, or the death of brain cells, is the most common side effect. I don’t get floaty or barely even get audio distortions anymore. Nitrous oxide (often referred to as laughing gas, whippets, cartridges, hippy crack, N2O, or nangs) is a gas inhalant used medically and recreationally as an anesthetic agent. Idk man. The use of nitrious can result in damage to the brain, but that is from a lack of oxygen to the brain, not from nitrous itself. I used to crush cases on psychedelics all damn day and love it. It is often believed that the effects of nitrous, which include euphoria, sound distortion, and minor to strong hallucinations, is caused by oxygen deprivation to the brain. This can be very painful and make walking difficult. But it’s different now. ); and the Section of Neurology, Hospital Universitari Doctor Josep Trueta, Girona (A.D.), Spain. All I get when I do a balloon now is this sensation of what feels like all the blood leaving my brain and that I might pass out. This research has focused largely on the narcotics4 and nitrous oxide.5,6 In many of these studies, the endpoints may be of limited clinical relevance (e.g. Put simply; consider the time you spend from emptying your lungs before you take the nitrous, until you begin breathing again. “In nitrous oxide, the oxygen is not free for respiration,” Bohlin says. This damage occurs when you don't breathe enough whilst taking nitrous.

Nitrous just feels like brain damage now. The main roles of nitric oxide in the brain Nitric oxide binds to guanylyl cyclase, the cyclic guanosine-monophosphate (cGMP)-producing enzyme which is a soluble NO receptor, and through cGMP-mediated signaling cascades it expresses its modulating effects either as a post- or a pre-synaptic retrograde messenger ( Wang et al., 2005 ). Although it is more common with children and the elderly, anyone who abuses nitrous oxide is at risk of brain cell loss, and specifically cells in areas that control memory and learning.